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采用测定趋化性的方法，观察了表皮生长因子（ＥＧＦ）和纤维连接蛋白（ＦＮ）对肺泡巨噬细胞（ＡＭ）趋化运动的影响。结果显示，ＥＧＦ能抑制ＡＭ的趋化性，量效关系显著（ｒ＝－０．９９１０，Ｐ＜０．０１），而ＥＧＦ本身对ＡＭ并不表现趋化吸引作用。ＦＮ亦能抑制ＡＭ的趋化性（Ｐ＜０．０１），ＥＧＦ和ＦＮ两者协同作用时，对ＡＭ趋化性的抑制程度大于各自的单独作用（Ｐ＜０．０１）。实验证明ＥＧＦ具有调节ＡＭ趋化运动的非促丝裂功能。提示肺内的细胞因子ＥＧＦ和细胞外基质成分ＦＮ参与肺部炎症及免疫反应的调控。
The effect of epidermal growth factor (EGF) and fibronectin (FN) on the chemotactic activity of alveolar macrophages (AM) was examined by measuring chemotaxis. The results showed that EGF can inhibit the chemotaxis of AM, the dose-effect relationship was significant (r = -0.9910, P <0.01), while EGF itself did not show chemotactic attraction to AM. FN also inhibits the chemotaxis of AM (P <0.01). When both EGF and FN act synergistically, the inhibition of AM chemotaxis is greater than that of AM (P <0.01). Experiments show that EGF has a non-mitogenic function to regulate AM chemotaxis. It is suggested that the intracellular factors EGF and extracellular matrix FN are involved in the regulation of lung inflammation and immune response.