论文部分内容阅读
目的探讨孕妇血清HBV DNA含量与母婴宫内传播的相关性。方法将196例HBV感染孕妇依据其分娩前血清HBV DNA含量(>1×106和≤1×106 copies/ml)分为两组,其新生儿出生后采用乙肝免疫球蛋白(HBIG)及乙肝疫苗(HBvac)治疗。检测两组孕妇分娩前血清HBV DNA含量、新生儿及7月龄婴儿血清HBV标志物(HBVM)。结果孕妇血清HBV DNA>1×106组和HBV DNA≤1×106组新生儿宫内感染率分别为42.7%和16.4%,两者比较差异有统计学意义(P<0.01)。HBV DNA>1×106组婴儿7月龄时HBsAg阳性率较HBV DNA≤1×106组高,而HBsAb阳性率较HBV DNA≤1×106组低,两组比较均有统计学意义(P<0.05)。结论孕妇血清中HBV DNA含量越高,发生母婴垂直传播的危险性越大,阻断效果也越差。
Objective To explore the correlation between serum HBV DNA level and intrauterine transmission in pregnant women. Methods 196 pregnant women with HBV infection were divided into two groups based on their serum HBV DNA levels before delivery (> 1 × 106 and ≤1 × 106 copies / ml). The newborns were immunized with HBIG and hepatitis B vaccine (HBvac) treatment. Serum HBV DNA levels before delivery in both groups were measured, and serum HBV markers (HBVM) were measured in newborns and 7-month-old infants. Results The rates of neonatal intrauterine infection of pregnant women with HBV DNA> 1 × 106 group and HBV DNA ≤ 1 × 106 group were 42.7% and 16.4%, respectively, with statistical significance (P <0.01). HBsAg positive rate of HBV DNA> 1 × 106 infants at 7 months of age was higher than that of HBV DNA ≤ 1 × 106, while the positive rate of HBsAb was lower than HBV DNA ≤ 1 × 106 group (P < 0.05). Conclusion The higher the serum HBV DNA content in pregnant women, the greater the risk of vertical transmission of mother to child and the poorer the blocking effect.