早在1905年Edkins发现了胃泌素(Gastrin),但直到1964年Gregory等才确定了胃泌素的一级结构并进行了人工合成。此后,胃泌素的研究进展甚快,其中特别是通过合成大量类似物,对胃泌素结构与功能的关系进行了比较深入的研究,积累了许多有价值的资料,本文着重对近年来这方面的工作加以综述。 As early as 1905, Edkins discovered gastrin, but it was not until 1964 that Gregory et al. Determined the primary structure of gastrin and synthesized it. Since then, gastrin research progresses very rapidly, especially through the synthesis of a large number of analogues, gastrin structure and function of a more in-depth study and accumulated a lot of valuable information, this article focuses on the recent years The work to be reviewed.