利用傅里叶变换红外(FTIR)光谱仪联合衰减全反射(ATR)探头的中红外光导纤维对46名健康志愿者及113名乳腺肿物患者的体表皮肤进行无创红外光谱测定,并从分子水平比较、分析了正常乳腺和有肿物乳腺体表皮肤的红外光谱特征.结果表明,健康志愿者乳房皮肤8个FTIR光谱测定部位的图谱趋于一致;正常乳腺体表与有肿瘤乳腺体表的吸收峰差异明显,而1080 cm-1处核酸相关吸收峰的变化对鉴别肿瘤的良、恶性有重要意义. The surface skin of 46 healthy volunteers and 113 patients with breast masses was examined by noninvasive infrared spectroscopy with Fourier Transform Infrared (FTIR) spectrometer and attenuated total reflection (ATR) The results showed that the profiles of 8 FTIR spectra in the breast skin of healthy volunteers tended to be the same. The distribution of normal breast and superficial mammary gland The difference of the absorption peak is obvious. The change of the nucleic acid absorption peak at 1080 cm-1 is important for distinguishing the malignant and benign tumors.