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目的了解海南省白塞病的临床特征,提高对白塞病的认识。方法回顾性分析海南医学院附属医院2000-2015年住院确诊的20例白塞病患者的临床资料。结果 20例患者中男性12例,女性8例,男女比例为1.5:1;发病年龄25~45岁,平均(33.5±13.8)岁;病程1个月~10年,平均(2.9±1.9)年;从出现症状到诊断的平均时间为(1.8±1.2)年;口腔溃疡、生殖器溃疡、皮肤病变、眼部损害是常见的临床表现,所占比例分别为100%、80%、70%、25%;针刺反应阳性率为40%;神经系统损害3例、心脏瓣膜病变1例,消化道损害1例;实验室检查无特异性。结论白塞病临床表现多变,可累及多系统,治疗前均应常规筛查结核,多种药物对本病有一定的疗效,但停药后容易复发,糖皮质激素和免疫抑制剂联合治疗可改善患者重要脏器病变。
Objective To understand the clinical features of Behcet’s disease in Hainan Province and to improve its understanding of Behcet’s disease. Methods The clinical data of 20 patients with Behcet’s disease diagnosed in hospital from 2000 to 2015 in Hainan Medical College Hospital were analyzed retrospectively. Results The 20 patients included 12 males and 8 females, with a ratio of 1.5: 1. The age of onset was 25-45 years, with an average of (33.5 ± 13.8) years. The course of disease ranged from 1 month to 10 years (mean, 2.9 ± 1.9) years ; The average time from symptom onset to diagnosis was (1.8 ± 1.2) years; oral ulcers, genital ulcers, skin lesions and ocular lesions were common clinical manifestations, accounting for 100%, 80%, 70%, 25% %; Acupuncture reaction positive rate was 40%; 3 cases of nervous system damage, heart valve disease in 1 case, gastrointestinal damage in 1 case; laboratory tests without specificity. Conclusion The clinical manifestations of Behcet’s disease are varied and may involve multiple systems. Before treatment, tuberculosis should be routinely screened. A variety of drugs have a certain curative effect on the disease, but relapse after stopping is easy. The combined treatment of glucocorticoid and immunosuppressive agents Can improve the patient’s vital organs lesions.