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目的探讨脑脊液置换联合鞘内注射小剂量地塞米松和头孢曲松辅助治疗化脓性脑膜炎的临床疗效。方法化脓性脑膜炎48例,其中12例采用常规治疗作为对照组,36例在常规治疗的基础上加用置换脑脊液并联合鞘内注射头孢曲松和小剂量地塞米松,将其作为实验组,观察两组间的疗效差异。结果实验组的观察指标较对照组改善迅速,体温降至正常的时间平均缩短8.5天左右,周围血象降至正常平均缩短6天左右,脑脊液中自细胞降至正常平均缩短8天左右,平均住院时间缩短10天。结论加用脑脊液置换联合鞘内注射小剂量地塞米松和头孢曲松治疗化脓性脑膜炎,其效果明显优于常规治疗,可以明显缩短化脓性脑膜炎患者的住院时间,临床推广应用价值显著。
Objective To investigate the clinical efficacy of cerebrospinal fluid replacement combined with intrathecal injection of low-dose dexamethasone and ceftriaxone in the treatment of purulent meningitis. Methods 48 cases of purulent meningitis, of which 12 cases of conventional treatment as a control group, 36 cases of conventional therapy based on the addition of replacement of cerebrospinal fluid and intrathecal ceftriaxone and low-dose dexamethasone, as the experimental group , Observe the difference between the two groups. Results In the experimental group, the observation indexes improved rapidly compared with the control group. The mean time to body temperature was shortened by about 8.5 days on average and the peripheral blood was reduced to the normal average about 6 days. The average length of stay in the cerebrospinal fluid decreased from normal to normal after 8 days. Shorten the time by 10 days. Conclusion The combination of cerebrospinal fluid replacement and intrathecal injection of dexamethasone and ceftriaxone in the treatment of purulent meningitis is obviously superior to conventional treatment, which can significantly reduce the length of hospital stay in patients with purulent meningitis and has a great clinical value.