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目的 了解宫腔形宫内节育器 (Cu30 0 )及TCu2 2 0C、TCu380A3种宫内节育器 (IUD)放置1 0年的临床效果。方法 全国 7个IUD临床应用中心 ,对 2 699例随机放置Cu30 0、TCu2 2 0C和TCu380A的农村妇女 ,共观察 1 0年。结果 使用 1 0年时 ,Cu30 0、TCu2 2 0C和TCu380A的带器妊娠率 ,分别为 2 56、4 82和 4 0 1 / 1 0 0妇女 ,Cu30 0明显低于其他两种IUD(P <0 0 5)。脱落率分别为 4 54、5 46和 9 68/ 1 0 0妇女 ,TCu380A显著高于其他两种IUD(P <0 0 0 1 )。因出血、疼痛取出率分别为6 71、5 58和 6 80 / 1 0 0妇女 ,3种IUD比较 ,差异无显著意义 (P >0 0 5)。使用 1 0年时 ,3种IUD的续用率分别为 74 86、66 2 2和 63 56/ 1 0 0妇女 ,以Cu30 0续用率最高 ,TCu380A最低 (P <0 0 1 )。结论 Cu30 0、TCu2 2 0C和TCu380A的避孕效果好 ,可推广使用
Objective To understand the clinical effect of intrauterine IUD (Cu30 0) and TCu220C and TCu380A3 intrauterine devices (IUD) for 10 years. Methods Seven IUD Clinical Application Centers nationwide were observed in 2 699 rural women randomly assigned to Cu30 0, TCu2 2 0C and TCu380A for 10 years. Results The pregnancy rates of Cu30 0, TCu2 2 0C and TCu380A in 10 0 years were respectively 2 56,4 82 and 4 0 1/1 0 0 women, Cu 30 0 was significantly lower than those of the other 2 IUDs (P < 0 0 5). TCu380A was significantly higher in women with exfoliated rates of 545, 466 and 968/100, respectively, than the other two IUDs (P <0.01). There were no significant differences between the three types of IUDs (P> 0.05) in women with bleeding and pain removal rates of 6 71,5 58 and 6 80/1 0 0, respectively. After 10 years of use, the three IUDs continued to be 74 86, 662 2 and 63 56/1 0 0, respectively, with the highest Cu30 0 recovery rate and the lowest TCu 380A (P 0 01). Conclusion Cu30 0, TCu2 2 0C and TCu380A contraceptive effect is good, can be widely used