论文部分内容阅读
先天性白内障是导致儿童低视力及盲的常见眼科疾病之一.在众多致病因素中,遗传因素占首要地位.随着分子生物学技术的发展,已经明确了与先天性白内障有关的基因近30余个,且数量仍在不断增加.更多致病基因的发现及其功能的研究对于了解晶状体的生物学特性和白内障的病理生理学机制具有重要的价值,这有利于寻找预防白内障的新方法,使个体化基因干预成为可能.本研究从晶状体胚胎学及与先天性白内障相关的基因两方面就先天性白内障致病基因的研究进展进行综述.“,”Congenital cataract is one of the leading causes of children vision impairment and blindness.Among the many causative factors,inheritance plays a critical role in the development of congenital cataract.With the development of molecular biology techniques,more than 30 genes have been found to be associated with congenital cataract,and the number is still increasing.More pathogenic genes discovery and functional researches have the important values to understand the lens biological characteristics and the cataract pathophysiology mechanism.Discovering new ways to prevent cataracts may make it possible for human to achieve individualized genetic intervention.This article reviewed the recent advances in the study of lens embryology and genes related to congenital cataract.