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目的观察氯沙坦联合辛伐他汀治疗早期糖尿病肾病的临床疗效及作用机制。方法 89例2型糖尿病合并早期糖尿病肾病及血脂异常患者,随机分为单用氯沙坦组(对照组)和氯沙坦联用辛伐他汀组(观察组),观察治疗前后2个月两组患者血脂、尿白蛋白排泄率(UAER)及C反应蛋白的变化情况。结果治疗2个月后,两组尿白蛋白排泄率均明显下降,观察组尿白蛋白排泄率、血清TC、血TG、血清LDL和血清C反应蛋白的下降明显优于对照组(P<0.05)。结论氯沙坦与辛伐他汀联用治疗早期DN可明显降低UAER,还具有一定的调脂和抗炎作用。
Objective To observe the clinical efficacy and mechanism of losartan combined with simvastatin in the treatment of early diabetic nephropathy. Methods Eighty-nine patients with type 2 diabetes mellitus complicated with early diabetic nephropathy and dyslipidemia were randomly divided into losartan group (losartan group) and losartan plus simvastatin group (observation group), two months and two months before and after treatment Group of patients with blood lipids, urinary albumin excretion rate (UAER) and C-reactive protein changes. Results After two months of treatment, the urinary albumin excretion rate was significantly decreased in both groups. The urinary albumin excretion rate, serum TC, blood TG, serum LDL and serum C-reactive protein in the two groups were significantly lower than those in the control group (P <0.05 ). Conclusion Losartan combined with simvastatin treatment of early DN can significantly reduce UAER, but also has some lipid-lowering and anti-inflammatory effects.