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氨茶碱是一种支气管扩张剂,常用于治疗阻塞性肺部疾患.已知的副反应有恶心、腹泻和心律不齐等.作者报告1例氨茶碱所致的严重即刻型超敏反应.患者83岁女性,因长期肺气肿伴发阻塞性肺部疾病加剧入院.患者曾用小剂量强的松、间羟异丙基肾上腺素喷雾剂和氧气吸入治疗,无水茶碱片已在两月前停用.入院后,给予β-肾上腺素能吸入剂和300mg氨茶碱负荷剂量静注.注药后10分钟,患者发生全身性荨麻疹,同时血压下降.经过输液,静注100mg甲基强的松龙和50mg盐酸苯海拉明后,血压恢复正常,瘙痒缓解.
Aminophylline is a bronchodilator commonly used in the treatment of obstructive pulmonary disease, and known side effects include nausea, diarrhea, arrhythmia, etc. The authors report a case of severe immediate-type hypersensitivity caused by aminophylline 83-year-old woman admitted to hospital due to long-term emphysema with obstructive pulmonary disease who had been treated with low-dose prednisone, meta-isoproterenol spray and oxygen inhalation, and anhydrous theophylline tablets Was discontinued two months ago and was given a beta-adrenergic inhalant and a 300 mg aminophylline bolus intravenously at 10 minutes after injection, with systemic urticaria and a drop in blood pressure. After 100 mg of methylprednisolone and 50 mg of diphenhydramine hydrochloride, blood pressure returned to normal and itching relieved.