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药物疗效及肿瘤的复发转移是影响大肠癌患者预后的主要因素。随着肿瘤分子生物学领域的研究进展,出现了一些新的相关标志物,其中研究较多的基因肿瘤标志物,如ras基因、BRAF基因、C-erbB-2基因、MMR基因、PIK3CA、PI3K、PTEN等。这些基因的突变及功能异常均可影响大肠癌的发生、发展、药物疗效及预后,成为目前研究的热点,该文就这些基因标志物与大肠癌疗效及预后的关系作一综述。
Drug efficacy and tumor recurrence and metastasis affect the prognosis of patients with colorectal cancer is the main factor. With the progress in the field of tumor molecular biology, some new related markers have emerged. Among them, more research has been made on gene tumor markers such as ras gene, BRAF gene, C-erbB-2 gene, MMR gene, PIK3CA, PI3K , PTEN and so on. The mutation and dysfunction of these genes can affect the occurrence, development, drug efficacy and prognosis of colorectal cancer, and become a hot spot in this field. This article reviews the relationship between these gene markers and the efficacy and prognosis of colorectal cancer.