动脉粥样硬化性心血管疾病(ASCVD)受环境和遗传因素的共同影响。补体第三组分(C3)是补体系统重要组成部分。近年来研究表明,C3基因多态性可能影响C3的表达,并与冠心病、脑梗塞等ASCVD有关,但研究结论尚不一致。本文结合国内外研究现状,对补体C3基因多态性与ASCVD的关系做一综述。 Atherosclerotic cardiovascular disease (ASCVD) is influenced by both environmental and genetic factors. The third component of complement (C3) is an important part of the complement system. In recent years, studies have shown that C3 gene polymorphisms may affect the expression of C3, and coronary heart disease, cerebral infarction and other ASCVD, but the conclusions are not consistent. In this paper, the current status of research at home and abroad, complement C3 gene polymorphism and ASCVD are reviewed.