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目的盐酸乌司他丁做类表面麻醉喷雾剂,在小儿全麻插管前应用,观察术后麻醉苏醒期拔管后发声情况。方法 60例小儿择期短时手术随机分三组,全麻诱导插管前I组用1%丁卡因液喷雾咽喉及导管球囊端;II组用复方利多卡因乳膏涂抹导管球囊端;III组用1:5000单位乌司他丁液喷雾咽喉及导管球囊端,顺势插管维持麻醉,60min内完成手术进入麻醉苏醒期准备拔管。结果三组麻醉苏醒期均可短时自然恢复自主呼吸及意识。I、II组能耐受带管拔管后有声音嘶哑,而III组不能耐受带管拔管后无声嘶。结论用蛋白酶抑制剂乌司他丁作小儿全麻插管前类表麻应用,有预防拔管后声嘶奇效。
Objective Ulinastatin hydrochloride is used as topical anesthetic spray, applied before pediatric anesthesia intubation, and observed after anesthesia recovery. Methods Sixty children undergoing elective short-term surgery were randomly divided into three groups. Group A was given intratracheal instillation with general anesthesia, and throat and catheter were sprayed with 1% tetracaine solution. Group II was treated with compound lidocaine cream ; Group III with 1: 5000 unit ulinastatine spray throat and catheter balloon end, homeopathic intubation to maintain anesthesia, 60min to complete the operation into the anesthesia recovery period for extubation. Results All three groups of anesthesia recovery period can spontaneously resume spontaneous breathing and consciousness in a short period of time. Groups I and II were able to tolerate hoarseness after extubation, while group III could not tolerate hoarseness after extubation. Conclusion Ulinastatin as a protease inhibitor for general anesthesia in children before anesthesia cannabis ephedrine anesthesia to prevent the effect of hoarseness after extubation.