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目的探讨胰岛素抵抗与复发性流产的关系。方法选择2009年12月至2010年12在我院就诊有复发性流产史的孕妇102例作为观察组,同期就诊的无不良孕产史的早期妊娠孕妇88例作为对照组,均与妊娠5～13周行葡萄糖耐量实验及胰岛素释放实验,计算胰岛素抵抗指数(HOMA-IR),比较观察组和对照组的糖代谢及胰岛素抵抗情况。结果①两组比较,空腹血糖,空腹胰岛素,1h胰岛素及HOMA-IR,差异无统计学意义(P>0.05)。②两组比较,OGTT后1h,2h血糖,2h胰岛素,观察组大于对照组,差异有统计学意义(P<0.05)。结论有复发流产史的患者孕早期胰岛素抵抗较普通孕妇增加。
Objective To investigate the relationship between insulin resistance and recurrent spontaneous abortion. Methods A total of 102 pregnant women with recurrent spontaneous abortion in our hospital from December 2009 to December 2010 were selected as the observation group. 88 pregnant women with no history of adverse pregnancy during the same period were selected as the control group, After 13 weeks, glucose tolerance test and insulin release test were performed to calculate the insulin resistance index (HOMA-IR). The glucose metabolism and insulin resistance of the observation group and the control group were compared. Results ① There were no significant differences in fasting blood glucose, fasting insulin, insulin 1h and HOMA-IR between the two groups (P> 0.05). ②Comparison between two groups showed that the levels of blood glucose, 2h insulin and observation group were significantly higher than those of the control group at 1h, 2h after OGTT, the difference was statistically significant (P <0.05). Conclusions Patients with recurrent spontaneous abortion have more insulin resistance in early pregnancy than normal pregnant women.