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目的 :研究谷胱甘肽转硫酶T1、M1(GSTT1、GSTM 1)基因多态性和烟酒茶嗜好及其相互作用与食管癌、胃癌易感性的关系。方法 :在上消化道癌高发区淮安市进行了病例 -对照研究 (食管癌 141例 ,胃癌 15 3例 ;人群对照 2 2 3例 ) ,调查研究对象的烟酒茶嗜好习惯 ,以多重PCR方法分析GSTT1、GSTM1基因型。结果 :食管癌组GSTM1-基因型频度 (75 .18% )显著高于对照组 (5 9.6 4 % ,P =0 .0 0 2 4 ;多因素调整OR =2 .33,95 %CI =1.39～ 3.92 )。吸烟或不饮茶与GSTM 1 基因型在增加食管癌发生的风险中有明显的协同作用。在GSTT1+基因型者中 ,吸烟习惯显著增加食管癌、胃癌的危险性 ;在GSTM1+基因型者中 ,经常饮酒显著增加食管癌、胃癌的危险性。结论 :食管癌、胃癌的发生与生活习惯、GSTM1和GSTT1基因型以及它们的相互作用有关。
Objective: To investigate the relationship between glutathione S-transferase T1, M1 (GSTT1, GSTM1) gene polymorphisms, smoking and drinking habits and their interactions with esophageal cancer and gastric cancer susceptibility. Methods: A case-control study (141 cases of esophageal cancer, 15 3 cases of gastric cancer and 223 cases of gastric cancer) was conducted in Huaian, a high incidence area of upper gastrointestinal cancer. The habit of smoking, GSTT1, GSTM1 genotypes were analyzed. Results: The frequency of GSTM1 genotype in esophageal cancer group was significantly higher than that in control group (75.18%, P = 0.002 4, multivariate adjusted OR = 2.33, 95% CI = 1.39 ~ 3.92). Smoking or not drinking tea and the GSTM1 genotype have a significant synergistic effect in increasing the risk of esophageal cancer. Among GSTT1 + genotypes, smoking habit significantly increased the risk of esophageal cancer and gastric cancer; in GSTM1 + genotype, frequent alcohol consumption significantly increased the risk of esophageal cancer and gastric cancer. Conclusion: The occurrence of esophageal cancer and gastric cancer is related to the living habits, GSTM1 and GSTT1 genotypes and their interaction.