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赤芍生药经石油醚脱脂、70%乙醇加热回流、减压浓缩、正丁醇提取、减压抽提得浅棕色不定形粉末(简称赤芍 D)。赤芍 D 的 LD_(50)是4.6±0.4g/kg(按生药剂量ip)。赤芍 D 对 S-180实体瘤有明显抑制作用,用药组与对照组比较有显著差异,P<0.05。此药与阈下量的环磷酰胺(2.5mg/kg)合用未见显著提高疗效。此药单独应用或与氨甲喋岭(0.5mg/kg)合用对615白血病小鼠的生存时间无明显影响。此药对静注 S-180
Red locust crude drug degreasing by petroleum ether, 70% ethanol heated reflux, vacuum concentration, n-butanol extraction, vacuum extraction of light brown amorphous powder (referred to as red peony D). The LD_(50) of Radix Paeoniae D was 4.6±0.4 g/kg (ip dose). Red peony D had a significant inhibitory effect on S-180 solid tumors, and there was a significant difference between the drug group and the control group, P<0.05. The use of this drug in combination with subthreshold cyclophosphamide (2.5 mg/kg) did not significantly improve efficacy. This drug alone or in combination with carbamazepine (0.5mg/kg) had no significant effect on the survival time of mice with 615 leukemia. This medicine is for intravenous injection S-180