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目的:比较紫硇砂醋制前后的化学成分变化,探讨其炮制减毒的物质基础。方法:采用硝酸银滴定法、紫外分光光度法、亚甲基蓝分光光度法、微波消解结合ICP-AES和指示剂变色等分析方法,比较紫硇砂醋制前后氯化钠、单质硫、硫化物、微量元素的含量变化并分析其炮制过程中释放的有害气体。结果:紫硇砂生品及醋制品中氯化钠含量均>85%,醋制后氯化钠含量略增;生品、醋制品中单质硫质量分数分别为87.75~144.56,19.21~28.54μg·g-1;不同批次生品中硫化物质量分数0.045%~0.061%,醋制品中均未检测出硫化物;有害元素As,Cd,Cr,Pb等含量降低,炮制过程中逸出的臭味气体为硫化氢。结论:醋制提净了紫硇砂药材,去除了部分潜在的毒性成分,炮制后化学成分变化较大,为该药味炮制减毒机制的物质变化基础提供参考。
OBJECTIVE: To compare the chemical composition before and after the purple aster vinegar system, and to explore its material basis for processing attenuated. Methods: Sodium nitrite titration, UV spectrophotometry, methylene blue spectrophotometry, microwave digestion combined with ICP-AES and indicator discoloration and other analytical methods before and after purple sand vinegar sodium chloride, elemental sulfur, sulfide, trace The content of elements changes and analyze the harmful gases released during the processing. Results: The contents of sodium chloride in the products of Aster sand and vinegar were all more than 85%, while the content of sodium chloride in vinegar was slightly increased. The contents of elemental sulfur in the products were 87.75 ~ 144.56 and 19.21 ~ 28.54μg · G-1; Sulfide mass fraction 0.045% ~ 0.061% in different batches of crude products, no sulfides were detected in the vinegar products; As, Cd, Cr, Pb and other harmful elements were reduced, The odor gas is hydrogen sulfide. CONCLUSION: Aspartic acid extracted from Aster albacares, removing some of the potential toxic components, and the changes of chemical components after processing were large, which provided a reference for the material changes of the drug-induced attenuated mechanism.