Many different materials are available for grafting during surgery for Peyronie\'s disease (PD).To study the outcomes associated with the use of a lyophilized bovine pericardium graft (Peri-Guard(R)) to repair tunical defects in patients with PD descriptive study of 43 patients with disabling penile curvature was performed.Curvature was measured before and after the intervention using a standardized procedure.Surgical technique was plaque excision and grafting of the tunical defect carried out by a single surgeon.A lyophilized bovine pericardium patch was used for grafting.We measured the change in penile curvature and length the ability to perform successful sexual intercourse without further pharmacological or surgical treatment and the satisfaction with treatment.Follow-up data were available for a total of 41 patients.Median age was 50 years (I(;R 48-52);mean follow-up time was 14 ± 6 months.Complete penile straightening was achieved in 33 patients (80.5％) and five patients (12.2％) had curvature under 20°.Three months after surgery and stretching therapy mean (s.d.) flaccid penile length increased from 11.2 ± 2.8 cm to 12.1 ± 2.9 cm (P ＝ 0.062).Seventy-five percentage of patients reported being able to achieve successful intercourse without further treatment.Eighty-five percentage of patients reported to be satisfied with the treatment.There was no evidence of tissue rejection or infection and only four patients suffered an adverse event.Plaque excision and grafting of the tunical defect with lyophilized bovine pericardium seems to be a safe and effective treatment for patients with PD.