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目的探讨糖尿病肾病(DN)的相关因素,为DN的一级预防提供理论依据。方法选择2型糖尿病(T2DM)患者267例,其中DN患者102例(DN组),单纯糖尿病无肾病165例(NDN组),采集血糖等临床资料,进行t检验、χ~2检验和Logistic回归分析。结果组间比较显示,DN组与NDN组的年龄、糖尿病(DM)病程、BMI、吸烟、高脂饮食、合并高血压、FPG、2hPG、0.5hPG、HbA_1c、TC、TG、LDL-C和纤维蛋白原(Fib)差异有统计学意义(P<0.05或P<0.01)。多元Logistic回归分析中,DN的发生与DM病程、TC、HbA_1c、FPC、2hPC和合并高血压有关(P<0.05或P<0.01)。结论 TC、DM病程、HbA_1c、FPG、2hPG和合并高血压是DN发生的独立相关因素。
Objective To investigate the related factors of diabetic nephropathy (DN) and provide a theoretical basis for primary prevention of DN. Methods Totally 267 T2DM patients were enrolled in this study. Among them DN patients (DN group), DN group (n = 165) and DNN group (165 patients without nephropathy) were enrolled. Blood glucose and other clinical data were collected and analyzed by t test, analysis. Results The comparison among groups showed that age, duration of diabetes, BMI, smoking, high fat diet, hypertension, FPG, 2hPG, 0.5hPG, HbA1c, TC, TG, LDL-C and fiber in DN group and NDN group The difference of Fib was statistically significant (P <0.05 or P <0.01). Multivariate logistic regression analysis showed that the occurrence of DN was related to the course of DM, TC, HbA 1c, FPC, 2hPC and hypertension (P <0.05 or P <0.01). Conclusions The duration of TC, DM, HbA_1c, FPG, 2hPG and hypertension are independent related factors of DN.