目的:探讨转化生长因子β_2(TGF-β_2)对大鼠角膜针刺损伤愈合的影响。方法:雄性Wistar大鼠20只,均取右眼制造角膜针刺创伤模型后随机分成实验组和对照组,实验组用转化生长因子β_2(TGF-β_2)点眼,对照组用生理盐水点眼,每日6次,至创面愈合止。计算剩余损伤面积、行组织学检查及透射电镜观察。结果:术后两组创面愈合面积比较实验组均快于对照组,且差异显著,组织学检查及电镜观察均显示两组差异。结论:TGF-β_2有促进角膜损伤愈合的作用,其可能的机制为TGF-β_2是胶原溶酶的主要抑制剂,可抑制基质中胶原酶的合成,降低胶原分解,促进胶原的分泌。 Objective: To investigate the effect of transforming growth factor β_2 (TGF-β_2) on healing of rat cornea after acupuncture injury. Methods: Twenty male Wistar rats were randomly divided into experimental group and control group. The rats in the experimental group were treated with TGF-β 2, while those in the control group were treated with normal saline. Day 6 times, until the wound healing only. Calculate the remaining area of ​​injury, line histological examination and transmission electron microscopy. Results: The healing area of ​​the two groups after operation was faster than that of the control group, and the difference was significant. The differences between the two groups were showed by histological examination and electron microscope observation. CONCLUSION: TGF-β 2 can promote the healing of corneal injury. Its possible mechanism is that TGF-β 2 is the main inhibitor of collagenase, which can inhibit the synthesis of collagenase in the matrix, reduce collagen breakdown and promote the secretion of collagen.