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目的探讨等效剂量口服吗啡缓释片与芬太尼透皮贴剂治疗晚期消化道癌痛患者的临床疗效。方法选取疼痛数字分级法(NRS)≥5的晚期消化道癌痛患者120例,随机分为2组,用相等剂量吗啡,A组外用芬太尼贴剂,B组口服吗啡缓释片,观察2组患者疼痛缓解、生活质量改善情况及不良反应发生率。结果 2组用药后止痛效果明显,差异无统计学意义(P>0.05);A组不良反应明显低于B组,生活质量较治疗前改善明显,差异有统计学意义(P<0.05),2组便秘发生率差异有统计学意义(P<0.01)。结论芬太尼透皮贴剂是晚期消化道癌痛患者最理想的药物,使用方便,疗效确切,值得临床推广。
Objective To investigate the clinical efficacy of equivalent doses of oral morphine sustained-release tablets and fentanyl transdermal patches in patients with advanced gastrointestinal cancer pain. Methods A total of 120 patients with advanced gastrointestinal cancer pain with NRS ≥5 were randomly divided into two groups. Patients in group A were given morphine, fentanyl patch in group A, and oral morphine sustained-release tablets in group B, 2 patients with pain relief, quality of life improvement and the incidence of adverse reactions. Results The analgesic effects of the two groups were significant (P> 0.05). The adverse reactions in group A were significantly lower than those in group B. The quality of life improved significantly compared with that before treatment (P <0.05), and the difference was not statistically significant The incidence of constipation difference was statistically significant (P <0.01). Conclusion Fentanyl transdermal patch is the most ideal drug for patients with advanced gastrointestinal cancer pain. It is easy to use and effective and worthy of clinical promotion.