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基于核酸适体生物传感器检测多巴胺的不同原理,分别概述了电化学核酸适体传感器和光学核酸适体传感器检测多巴胺。这两种多巴胺的检测方法与传统方法相比具有明显的优势,如检测时间短、更易操作及检测范围更广等。采用这两种传感器检测多巴胺的浓度都已达到皮摩尔级的水平,响应时间小于1 s,且由于多巴胺适体的存在传感器表现出对多巴胺高度的特异性。未来将会把纳米技术和核酸适体传感器检测多巴胺紧密结合,从而大幅提高传感器的检测性能,同时核酸适体传感器检测多巴胺会向着集成化和便携式方向发展,以期能够得到更好的实际应用。
Based on the different principle of aptamer biosensor for the detection of dopamine, electrochemical aptamer sensor and aptamer aptamer were respectively reviewed to detect dopamine. Compared with the traditional methods, the detection methods of these two dopamine have obvious advantages, such as short detection time, easier operation and broader detection range. Both dopamine concentrations have been tested to picomolar levels using these two sensors with response times of less than 1 s and the presence of dopaminergic aptamers shows a high degree of specificity for dopamine. In the future, nano-technology and nucleic acid aptamer sensor will detect dopamine closely, which will greatly improve the detection performance of the sensor. Meanwhile, the detection of dopamine by the aptamer sensor will be more integrated and portable in the hope of getting better practical application.