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近年来认为不同的给药途径可明显地改变化合物的毒性作用。有人报导乙烯二胺四乙酸(以下简称EDTA)灌胃无致畸作用,而另有报导则提出肌肉注射或随饲料摄入EDTA均可导致畸胎。在这些研究的基础上,作者采用经口和非经口等不同方法给药以研究EDTA的比较毒性和致畸作用。将受孕大鼠随机分成7组,于受孕后第7～14天,按下列途径之一给药:1) 喂饲,含3%EDTA的饲料,平均用药954mg/kg/日;2) 灌胃,EDTA溶于磷酸钾缓冲液,剂量
In recent years, different routes of administration have been found to significantly alter the toxic effects of the compounds. It has been reported that ethylenediaminetetraacetic acid (hereinafter referred to as EDTA) gavage without teratogenic effect, while another report suggested that intramuscular injection of EDTA or feed intake can lead to teratogenic. Based on these studies, the authors administered different oral and non-oral methods to study the comparative toxicity and teratogenicity of EDTA. The pregnant rats were randomly divided into 7 groups, 7 to 14 days after conception, administered by one of the following ways: 1) feed, containing 3% EDTA feed, the average medication 954mg / kg / day; , EDTA dissolved in potassium phosphate buffer, the dose