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目的:探讨硫酸镁联合硝苯地平对妊娠期高血压疾病患者抗氧化能力及血液流变学两方面的影响。方法:选取2010年7月～2012年5月采用硫酸镁联合硝苯地平进行治疗的33例妊娠期高血压疾病患者为研究组,然后选取同期的33例采用硫酸镁进行治疗的患者为对照组,将两组治疗前和治疗后5天的血清MDA、GSH-Px、TAC、SOD及全血黏度、全血还原黏度进行比较。结果:两组治疗前的血清MDA、GSH-Px、TAC、SOD及全血黏度、全血还原黏度比较,P值均>0.05,而治疗后5天研究组的血清MDA及全血黏度、全血还原黏度均低于对照组,血清GSH-Px、TAC及SOD均高于对照组,P值均<0.05,有统计学差异。结论:硫酸镁联合硝苯地平对于妊娠期高血压疾病患者的抗氧化能力及血液流变学指标的改善发挥着积极的作用,临床价值较高。
Objective: To investigate the effects of magnesium sulfate combined with nifedipine on anti-oxidation and hemorheology in patients with hypertensive disorder complicating pregnancy. Methods: From July 2010 to May 2012, 33 patients with hypertensive disorder complicating pregnancy treated with magnesium sulfate and nifedipine were selected as the study group, and 33 patients treated with magnesium sulfate during the same period were selected as the control group The serum MDA, GSH-Px, TAC, SOD, whole blood viscosity and whole blood reduction viscosity of two groups before treatment and 5 days after treatment were compared. Results: Before treatment, the serum MDA, GSH-Px, TAC, SOD and whole blood viscosity, whole blood reduced viscosity, P values were all> 0.05, while the serum MDA and whole blood viscosity Blood viscosity reduction were lower than the control group, serum GSH-Px, TAC and SOD were higher than the control group, P <0.05, with statistical differences. Conclusion: Magnesium sulfate combined with nifedipine plays a positive role in the improvement of anti-oxidation and hemorrheological indexes in patients with hypertensive disorder complicating pregnancy. The clinical value is high.