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单独使用他汀类降脂药治疗时,许多患者的血浆脂蛋白达不到治疗目标,尤其是在多项血脂不正常的患者中,他汀类只能轻度的增高高密度脂蛋白(HDL-C):一种独立预测冠心病的因素和轻度的降低甘油三酯(TG)的作用。烟酸对增高HDL和降低TG有明显的药理作用。他汀类和烟酸类合用可以帮助患者控制低密度脂蛋白胆固醇(LDL-C)和升高HDL-C。
In patients treated with statin lipid-lowering drugs alone, plasma lipoproteins in many patients failed to achieve their therapeutic goals. In particular, in many patients with dyslipidemia, statins only mildly elevated high density lipoprotein (HDL-C ): An independent predictor of coronary heart disease and mild triglyceride (TG) lowering effects. Niacin has obvious pharmacological effects on increasing HDL and lowering TG. Statins and niacin can help patients control low-density lipoprotein cholesterol (LDL-C) and raise HDL-C.