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目的通过观察羟考酮与地佐辛配伍丙泊酚在无痛清宫术中的效果,探讨一种更安全舒适的麻醉方法 ,以满足无痛清宫术的麻醉需求。方法 200例自愿采用无痛方式进行清宫术的患者随机双盲分成丙泊酚复合羟考酮组(Q组)、丙泊酚复合地佐辛组(D组),每组100例。记录两组患者麻醉诱导前(T1)、麻醉后2 min(T2)、吸宫时(T3)、术毕(T4)时平均动脉压(MAP)、心率(HR)、脉搏血氧饱和度(Sp O2),以及离室时间、术后腹痛(子宫收缩痛)的视觉模拟评分(VAS)。结果 T1、T2、T3、T4时MAP、HR、Sp O2值两组组间比较差异无统计学意义(P>0.05);两组MAP、HR和Sp O2均在T2时间点出现下降,其中MAP与T1时刻比较差异有统计学意义(P<0.05);T3和T4时间点,MAP、HR和Sp O2的变化与T1时刻比较差异无统计学意义(P>0.05)。两组患者的离室时间比较差异无统计学意义(P>0.05);术后10 min两组VAS评分比较,差异有统计学意义(P<0.05)。结论在无痛清宫术中,羟考酮复合丙泊酚治疗术后子宫收缩痛较轻,麻醉效果较地佐辛好。
Objective To observe the effect of oxycodone and dexrazoxane in combination with propofol in painless hysteroscopy and to explore a safer and more comfortable method of anesthesia to meet the anesthesia requirement of painless hysteroscopy. Methods A total of 200 patients who underwent radical hysteroscopic painless surgery were randomly divided into propofol combined with oxycodone group (Q group) and propofol combined with dezocine group (D group), with 100 patients in each group. The mean arterial pressure (MAP), heart rate (HR) and pulse oximetry (Tmax) were recorded before anesthesia induction (T1), 2 min after anesthesia Sp O2), and visual analogue scale (VAS) of the time of leaving the room, postoperative abdominal pain (uterine contractions pain). Results The MAP, HR and Sp O2 values at T1, T2, T3 and T4 were not significantly different between the two groups (P> 0.05). The MAP, HR and Sp O2 in both groups decreased at T2, and MAP (P <0.05). There was no significant difference in the changes of MAP, HR and Sp O2 at T1 and T3 between T3 and T4 (P> 0.05). There was no significant difference between the two groups in the time of leaving the room (P> 0.05). There was significant difference in VAS score between the two groups 10 minutes after operation (P <0.05). Conclusions In painless hysteroscopy, oxycodone combined with propofol is effective in reducing postoperative uterine contractions and anesthesia is better than dezocine.