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目的观察新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)星形胶质细胞的变化及其与临床的关系。方法2002年1月至2005年12月通过对吉林大学第一医院25例新生儿HIE患儿脑病理标本进行免疫组化观察GFAP标记的星形胶质细胞的变化,进一步综合分析其与新生儿HIE的发生、病程的关系。结果25例新生儿HIE脑标本均可见不同程度的星形胶质细胞增生,小脑星形胶质细胞表现为生后24h内死亡者增生程度重(P<0.05),生存时间越长,增生程度反而较轻;慢性缺氧时大脑星形胶质细胞增生程度重(P<0.05),急性缺氧时延髓增生程度重(P<0.05),混合性缺氧大脑及延髓增生程度均较重(P<0.05)。结论新生儿HIE星形胶质细胞增生程度与HIE的发生、病程密切相关。
Objective To observe the changes of astrocytes in neonates with hypoxic-ischemic encephalopathy (HIE) and its relationship with clinical manifestations. Methods From January 2002 to December 2005, the changes of GFAP-labeled astrocytes in 25 neonates with HIE in Jilin University First Hospital were observed by immunohistochemistry. HIE occurred, the course of the relationship. Results 25 cases of neonatal HIE brain specimens were seen varying degrees of astrogliosis, cerebellar astrocytes showed severe post-operative death within 24h (P <0.05), the longer the survival time, the degree of proliferation (P <0.05). The degree of prolonged myelogenesis in acute hypoxia was heavier (P <0.05), and the degree of mixed hypoxic brain and bulbar hyperplasia were more serious P <0.05). Conclusion Neonatal HIE astrocyte hyperplasia is closely related to the occurrence and course of HIE.