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目的探讨夫西地酸治疗耐甲氧西林金黄色葡萄球菌(MRSA)感染性肺炎的临床效果。方法随机抽选本院收治的45例MRSA感染性肺炎患者,采用0.5 g的夫西地酸+250 ml 0.9%Nacl溶液,静脉滴注,1 h内滴注完毕,1次/8 h,观察连续治疗14 d后45例患者的临床疗效,细菌清除率以及安全性评价。结果 45例患者临床治疗总有效率达84.5%,细菌清除率为71.7%,治疗7、14 d后总胆红素(TBIL)、谷丙转氨酶(ALT)、尿素(Urea)、肌酐(CRE)等肝肾功能指标与治疗前比较差异有统计学意义(P<0.05),且更加趋近于正常值;均未出现明显不良反应。结论夫西地酸治疗MRSA肺炎的效果较好,安全性高,尤其是对于老年或肾功能不良的患者,可优先考虑选择该药治疗。
Objective To investigate the clinical efficacy of fusidic acid in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Methods Forty-five patients with MRSA pneumonia admitted in our hospital were randomly selected and treated with 0.5 g of fusidic acid and 250 ml of 0.9% Nacl solution. Intravenous instillation was performed within 1 hour and once / 8 hours. Clinical efficacy, bacterial clearance rate and safety evaluation of 45 patients after continuous treatment for 14 days. Results The total effective rate of clinical treatment was 84.5% and the bacterial clearance rate was 71.7% in 45 patients. The total bilirubin (TBIL), alanine aminotransferase (ALT), urea, creatinine (CRE) The liver and kidney function indexes were significantly different from those before treatment (P <0.05), and more close to normal values; no obvious adverse reactions were found. Conclusions Fusidic acid is effective and safe in the treatment of MRSA pneumonia, especially in patients with senile or renal dysfunction.