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很多与睡眠有关的神经递质和调质可影响脑内cAMP的代谢与含量,而在觉醒-睡眠周期中脑内cAMP含量亦发生相应变化,但未见应用多导睡眠描记术(PSG)研究中枢cAMP对睡眠影响的报道。本研究运用PSG方法观察了大鼠侧脑室注射外源性cAMP及其前体ATP对大鼠睡眠和觉醒的影响,以探讨中枢cAMP和ATP在睡眠和觉醒机制调节中的作用。1 材料和方法 实验选用9只体重200～260g雄性Wistar大鼠。动物饲养条件及记录电极安装同前。右侧脑室插
Many sleep-related neurotransmitters and tempering can affect the metabolism and content of cAMP in the brain, while the cAMP content in the awakening-sleep cycle also changes accordingly, but no application of polysomnography (PSG) study Central cAMP impact on sleep reports. In this study, PSG method was used to observe the effects of exogenous cAMP and its precursor ATP on the sleep and wakefulness of rats after intracerebroventricular injection of rat brain to investigate the role of central cAMP and ATP in the regulation of sleep and wakefulness mechanisms. MATERIALS AND METHODS One hundred and nine male Wistar rats weighing 200-260 g were selected. Animal feeding conditions and recording electrodes installed with the former. Right ventricle inserted