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近年来,慢性淋巴细胞白血病(CLL)的生物学和治疗方面有了很大的进展。这样就需要进一步认真对本病的诊断、分期和疗效标准再给予评价。定义和诊断 CLL是由于淋巴细胞肿瘤样增殖,通常涉及B-淋巴细胞克隆增殖。其特点为在外周血和骨髓中主要是小的、成熟淋巴细胞绝对和持续的增多。但应除外其他所有引起淋巴细胞增多的疾病。血中淋巴细胞计数通常等于或大于10×10~9/L。假如其他的条件达到诊断的标准,当淋巴细胞计数<10×10~9/L,也可诊断CLL,尤其是有持续的淋巴细胞增多。CLL的基本特征骨髓的浸润,能通过骨髓穿刺或活检标本的发现来证明。骨髓活检有核细胞中30%以上为淋巴细
In recent years, great progress has been made in the biology and treatment of chronic lymphocytic leukemia (CLL). This requires further careful diagnosis of the disease, staging and efficacy criteria to give evaluation. The definition and diagnosis of CLL is due to lymphoid tumor-like proliferation, usually involving the proliferation of B-lymphocyte clones. It is characterized by a predominantly small percentage in peripheral blood and bone marrow, with an absolute and sustained increase in mature lymphocytes. However, all other diseases that cause lymphocytosis should be excluded. The blood lymphocyte count is usually equal to or greater than 10 × 10 ~ 9 / L. If other conditions to achieve diagnostic criteria, when the lymphocyte count <10 × 10 ~ 9 / L, can also be diagnosed with CLL, especially with persistent lymphocytosis. The basic characteristics of CLL Bone marrow infiltration can be proved by bone marrow aspiration or biopsy specimens. Bone marrow biopsy nucleated cells in more than 30% of lymphocytes