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目的了解二甲双胍对耐克罗米酚的多囊卵巢综合征(PCOS)患者的治疗作用。方法28例耐克罗米酚PCOS患者经二甲双胍500mg每日三次治疗3个月,观察服药前后内分泌指标、体重指数(BMI)、腰臀围比值(WHR)、月经的变化及再加用克罗米酚促排卵情况。结果二甲双胍治疗后血黄体生成素/卵泡刺激素比值(LH/FSH)、睾酮(T)、空腹胰岛素均显著降低(P<0.05),而BMI、WHR、空腹血糖无明显变化(P>0.05),同时二甲双胍治疗后21.43%患者月经恢复正常,再次用克罗米酚促排卵有13例有排卵,排卵率为46.43%,其中4例指导性生活后妊娠。结论二甲双胍能改善耐克罗米酚PCOS患者的胰岛素抵抗及高雄激素血症,增强耐克罗米酚患者对克罗米酚的敏感性,是目前治疗PCOS新的辅助方法。
Objective To investigate the therapeutic effect of metformin on patients with polycystic ovary syndrome (PCOS) resistant to clomiphene. Methods 28 patients were treated with metoclopramide 500 mg three times a day for 3 months. The changes of endocrine index, body mass index (BMI), waist-hip ratio (WHR), menstrual changes and clomiphene Phenol ovulation situation. Results After metformin treatment, LH / FSH, T and fasting insulin were significantly decreased (P <0.05), while BMI and WHR had no significant changes (P> 0.05) , While menstruation returned to normal in 21.43% of patients treated with metformin. Once again ovulation was induced by clomiphene in 13 cases, with an ovulation rate of 46.43%, of which 4 were post-pregnancy-oriented pregnancies. Conclusion Metformin can improve the resistance to insulin resistance and hyperandrogenism in patients with niacin-loaded PCOS and enhance the sensitivity of clomiphene to niacin in patients with PCOS. It is a new adjunct to PCOS.