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骨髓来源免疫抑制细胞(myeloid derived suppressor cells,MDSCs)是一群异质性的骨髓来源的未成熟前体细胞,它们在肿瘤微环境中大量聚集,阻碍T细胞的抗肿瘤免疫应答反应。MDSCs的产生、聚集和发挥促肿瘤功能依靠STAT3、IL-1β/NF-κB、PI3K/AKT/m TOR、PGE2/Cox2及RAS信号通路的调节,信号通路的调节紊乱导致骨髓造血功能异常,形成具有免疫抑制功能的骨髓来源细胞,在肿瘤间质中聚集形成免疫抑制微环境。了解这些信号通路,特别是STAT3信号通路,能帮助我们理解恶性肿瘤中MDSCs功能的分子机制,找到一些消除肿瘤微环境中MDSCs的方法。
Bone marrow-derived myeloid derived suppressor cells (MDSCs) are a group of heterogeneous bone marrow-derived immature progenitor cells that accumulate in the tumor microenvironment in a large amount, hindering the anti-tumor immune response of T cells. The generation and accumulation of MDSCs and the promotion of tumorigenesis depend on the regulation of STAT3, IL-1β / NF-κB, PI3K / AKT / m TOR, PGE2 / Cox2 and RAS signaling pathways, Bone marrow-derived cells with immunosuppressive function accumulate in the tumor stroma to form immunosuppressive microenvironments. Understanding these signaling pathways, especially the STAT3 signaling pathway, helps us to understand the molecular mechanisms underlying the function of MDSCs in malignancies and to find ways to eliminate MDSCs in the tumor microenvironment.