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胰岛素抵抗(insulin resistance,IR)是代谢综合征(meta- bolie syndrome,MS)发病的中心环节,它不仅包括一般的代谢性疾病,同时也包括妇科肿瘤在内的常见的恶性肿瘤。胰岛素抵抗导致高胰岛素血症,由于胰岛素(insulin,IS)与胰岛素样生长因子(insulin-like growth factor,IGF)的作用,可增加妇科恶性肿瘤的发病危险;胰岛素抵抗存在时,炎症介质的作用在妇科恶性肿瘤发病过程中亦起重要作用。反过来,妇科恶性肿瘤的治疗过程中由于化疗药物的使用又可产生胰岛素抵抗。胰岛素抵抗与妇科恶性肿瘤关系密切,本文就这一方面作一综述。
Insulin resistance (IR) is the central part of the pathogenesis of meta-bolie syndrome (MS). It includes not only common metabolic diseases, but also common malignant tumors including gynecological tumors. Insulin resistance leads to hyperinsulinemia, which may increase the risk of gynecologic malignancies due to the effects of insulin (IS) and insulin-like growth factor (IGF); the role of inflammatory mediators in the presence of insulin resistance In the incidence of gynecological malignancies also play an important role. In turn, the treatment of gynecological malignancies due to the use of chemotherapy drugs can produce insulin resistance. Insulin resistance and gynecologic malignancies are closely related, this article makes a review on this aspect.