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目的系统评价血管紧张素Ⅰ转换酶(ACE)基因插入/缺失(I/D)多态性与力量型(爆发力)运动能力的相关性。方法计算机检索Pub Med、EMbase、CNKI、CBM、VIP和Wan Fang Data数据库,搜集关于ACE基因I/D多态性与力量型运动能力相关性的病例-对照研究,检索时限均为建库至2015年8月1日。由2位评价者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用Rev Man 5.3软件进行Meta分析。结果最终纳入26个病例-对照研究,共计2 032例运动员和10 600例对照。Meta分析结果显示:ACE基因I/D多态性与力量型运动能力无相关性[DD vs.DI+II:OR=1.05,95%CI(0.81,1.36),P=0.70;DD+DI vs.II:OR=1.03,95%CI(0.82,1.29),P=0.80;DD vs.II:OR=1.04,95%CI(0.74,1.47),P=0.82;DI vs.II:OR=0.99,95%CI(0.81,1.22),P=0.96;D vs.I:OR=1.04,95%CI(0.88,1.24),P=0.62]。按种族进行的亚组分析结果显示,ACE基因I/D多态性与不同种族运动员力量型运动能力均无相关性。结论现有证据表明,ACE基因I/D多态性与运动员力量型运动能力之间不存在关联性。受纳入研究质量的限制,上述结论仍需进一步开展设计合理、方法得当的病例-对照研究或队列研究予以证实。
Objective To evaluate the relationship between ACE gene insertion / deletion (I / D) polymorphism and strength (explosive) motor ability. Methods The databases of Pub Med, EMbase, CNKI, CBM, VIP and Wan Fang Data were searched by computer, and the case-control study on the relationship between ACE gene I / D polymorphism and strength-type motor ability was collected. August 1, After two reviewers independently screened the literature, extracted data, and assessed the risk of inclusion in the study, the Meta-analysis was performed using Rev Man 5.3 software. The results eventually included 26 case-control studies, totaling 2,032 athletes and 10,600 controls. Meta-analysis showed no correlation between ACE gene I / D polymorphism and strength-type exercise capacity [DD vs. DI + II: OR = 1.05,95% CI 0.81,1.36, P = 0.70; DD + DI vs .ID: 1.03, 95% CI (0.82,1.29), P = 0.80; DD vs. II: OR = 1.04, 95% CI , 95% CI (0.81, 1.22), P = 0.96; D vs. I: OR = 1.04, 95% CI (0.88, 1.24), P = 0.62]. Subgroup analysis by race showed ACE gene I / D polymorphism had no correlation with strength type athletic ability of different race athletes. Conclusions The available evidence suggests that there is no association between ACE gene I / D polymorphism and athlete strength-type athletic performance. Subject to inclusion of the quality of the study, the above conclusion still needs to be further confirmed by well-designed and well-matched case-control or cohort studies.