恶性血液病患者防治感染是一个重要问题。氟喹诺酮类的抗菌谱广,对中性粒细胞减少患者,诺氟沙星可使革兰阴性菌感染率减少,但对革兰阳性菌和真菌感染没有影响。氧氟沙星和依诺沙星也可使这些患者的发烧和感染性疾病减少。在一随机研究中,对比环丙沙星和复方新诺明加多粘菌素E,发现环丙沙星可预防革兰阴性菌感染的发 Prevention and treatment of infection in patients with hematological malignancies is an important issue. Fluoroquinolones broad antibacterial spectrum for neutropenia patients, norfloxacin can reduce the rate of gram-negative bacteria infection, but no effect on Gram-positive bacteria and fungal infections. Ofloxacin and enoxacin also reduced these patients’ febrile and infectious diseases. In a randomized study, comparing ciprofloxacin with compound norethisteromycin E, ciprofloxacin was found to prevent gram-negative bacterial infections