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Aβ传入纤维的兴奋传递在慢性痛的病理机制中起重要作用.动物实验证实其可能机理为增加脊髓后角的兴奋性,减低抑制性尤其是神经性疼痛和促使结构重组。关于慢性疼痛患者Aβ纤维感受阈值的研究较少报道,本研究拟检测慢性颈臂痛(CCB)患者对机械刺激感受阈值的变化,以期阐明Aβ纤维在疾病维持和适应过程中的作用。 对象和方法 研究对象为同一疼痛治疗中心的39例(男16,女23)难治性CCB患者,病程平均为7年,均排除了神经根病。首先对C_3～C_7颈髓神
Excitatory transmission of Aβ afferent fibers plays an important role in the pathological mechanism of chronic pain, and animal experiments show that its possible mechanism is to increase the excitability of spinal dorsal horn, reduce the inhibition, especially the neuropathic pain and promote the structural reorganization. However, few reports have been reported on the threshold of Aβ fibrillation in chronic pain patients. This study was designed to examine the changes of mechanical stimulation threshold in patients with chronic neck pain (CCB) to clarify the role of Aβ in the maintenance and adaptation of the disease. Subjects and Methods The study included 39 patients (16 males and 23 females) who were refractory to CCB at the same pain treatment center, with an average duration of 7 years, with exclusion of radiculopathy. First of C_3 ~ C_7 cervical spinal cord