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采用放免法检测了３８例原发性肾病综合征患儿及１７例健康儿童的血清总ＩｇＥ水平。结果显示，极期肾病患儿的血清ＩｇＥ水平显著上升（极期：１．２４１±１．１８１ｍｇ／Ｌ，对照组：０．２３６±０．２１６ｍｇ／Ｌ，Ｐ＜０．０１），而缓解期肾病患儿的血清ＩｇＥ水平下降，基本达到健康儿水平（０．３１５±０．１６３ｍｇ／Ｌ，Ｐ＞０．０５）。在ＩｇＥ水平升高组患儿，均达到部分或完全缓解，而ＩｇＥ不升高组患儿中，有２１％对皮质类固醇激素不敏感。频复发肾病患儿的血清ＩｇＥ水平明显高于非频复发组肾病患儿（前者１．６０６±１．５０９ｍｇ／Ｌ，后者０．５６２±０．４３１ｍｇ／Ｌ，Ｐ＜０．０５）。表明血清ＩｇＥ水平与本病临床关系密切，可作为预测激素反应以及判断复发频度的指标。
Serum total IgE levels were measured by radioimmunoassay in 38 children with primary nephrotic syndrome and 17 healthy children. The results showed that the level of serum IgE was significantly increased in children with extremely stage renal disease (extreme stage: 1.241 ± 1.181 mg / L, control group: 0.236 ± 0.216 mg / L, P <0.01) The level of serum IgE in children with stage renal disease decreased, reaching the level of healthy children (0.315 ± 0.163mg / L, P> 0.05). Partial or complete remission was achieved in children with elevated IgE, whereas 21% of those with IgE did not elevate corticosteroids. Serum IgE levels were significantly higher in children with frequency-recurrent nephropathy than those in frequency-refractory relapse patients (1.606 ± 1.509 mg / L for the former and 0.562 ± 0.431 mg / L for the latter, P <0.05). This indicates that serum IgE levels are closely related to the clinical status of the disease and can be used as an index to predict the hormone response and determine the frequency of recurrence.