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DAG对体外培养S180细胞及体内W256,L1210等10种瘤株均有不同程度活性;对L1210的治疗指数为5.4;分别与阿糖胞苷和甲氨喋昤合用有一定的协同作用;1次ip,小鼠LD_(50)为9.9±0.6mg/kg;家兔亚急性毒性主要表现为WBC减少。大剂量DAG可使犬急性血压、心率及呼吸出现轻度可逆性改变。
DAG had different degrees of activity in cultured S180 cells and 10 tumor lines such as W256 and L1210 in vitro. The therapeutic index to L1210 was 5.4. There was a synergistic effect with the combination of cytarabine and methamidoguanidine. Ip, mice LD_ (50) was 9.9 ± 0.6mg/kg; subacute toxicity in rabbits mainly showed a decrease in WBC. Large doses of DAG can cause mild reversible changes in acute blood pressure, heart rate, and breathing in dogs.