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考察茶碱缓释剂于不同时间给药时的体内药动学差异。结果发现,茶碱在体内的血药浓度有着明显的时间节律性。白天用药达峰时间短,血药浓度高,疗效也较明显。
To investigate the difference of pharmacokinetics of theophylline sustained-release agent when administered at different times. The results showed that the theophylline in vivo blood concentration has a significant time rhythm. Peak medication time during the day is short, high blood concentration, the effect is more obvious.