药物进入机体后,在酶系统作用下常发生一系列生化变化,如进行氧化、还原、水解、脫羧、环合等反应。这些生物转化反应可使药物失去活性,但是一个体外试验无效的化合物,也可能在代谢中释放出有效的化学结构,而显现出特殊的治疗作用。百浪多息在体內转变成磺胺就是一个著名的例子。象百浪多息这种具有潛在有效化学结构的药物,可称为潛伏性药物。有意识的改变一些有效药物的化学结构使成潛伏性,卽药物潛伏化(drugLatentiation),常可克服原药的很多缺点,获得更优良的药物,因此近年来受到了很大的重 Drugs into the body, the enzyme system under the action of a series of biochemical changes often occur, such as oxidation, reduction, hydrolysis, decarboxylation, cyclization and other reactions. These bioconversion reactions can inactivate drugs, but a compound that is ineffective in vitro may also release a potent chemical structure in metabolism that shows a special therapeutic effect. One of the notable examples is the shift in the body of sulphonamide. Like a hundred waves interest rate of this potentially effective chemical structure of the drug, may be called latent drugs. Consciously changing the chemical structure of some of the active drugs makes them potentially latent and drug drug latencies, often overcoming many of the drawbacks of the drug and getting better medicines, have gained a great deal of weight in recent years