背景与目的:许多研究发现一些分子标志物是重要的预后因素,然而catenins和cyclinD1在鼻咽癌中的价值尚不明确。本研究目的在于探讨鼻咽低分化鳞癌组织中连环蛋白α-、β-和γ-catenin以及细胞周期蛋白cyclinD1的表达,与临床因素及预后的关系。方法:38例鼻咽癌组织的石蜡标本,采用免疫组织化学方法检测α-、β-和γ-catenin和cyclinD1以及肿瘤增殖活性指标ki-67在肿瘤细胞中的表达。结果:本组标本中α-、β-和γ-cate-nin和cyclinD1低表达者略多。它们表达的高低与原发肿瘤T分期、淋巴结有无转移、临床分期和原发肿瘤体积相关性无显著性差异,各标志物的表达与肿瘤增殖活性指标ki-67高低亦未显示明显相关。单因素分析显示,β-cate-nin低表达患者的5年总生存率和无瘤生存率均明显低于高表达者,其值分别为53.2%、29.0%和81.9%、76.0%(P<0.05)。影响患者无瘤生存率的预后因素中,α-catenin的差异达到临界意义(P=0.061)。结论:α-、β-和γ-catenin和cyclinD1在鼻咽癌组织中存在异常表达,初步研究未发现表达异常与肿瘤增殖,分期和转移等存在相关性。仅β-catenin表达降低是影响患者生存率的一个不利预后因素。对这些分子标志物临床意义的检测必须扩大样本量,才有可能为今后的分子靶向治疗提供依据。 BACKGROUND & AIM: Many studies have found that some molecular markers are important prognostic factors. However, the value of catenins and cyclinD1 in NPC is unknown. The aim of this study was to investigate the expression of c-jun, cyclinD1 and c-jun in the poorly differentiated squamous cell carcinoma of the nasopharynx and its relationship with clinical factors and prognosis. Methods: The paraffin specimens from 38 cases of nasopharyngeal carcinoma were detected by immunohistochemical method for the expression of α-, β- and γ-catenin and cyclinD1 and the proliferation of tumor cells ki-67 in tumor cells. Results: In this group of specimens, the expression of α-, β- and γ-cate-nin and cyclinD1 were slightly lower. There was no significant difference between the expression level of T lymph node and the primary tumor T stage, lymph node metastasis, clinical stage and the primary tumor volume. The expression of each marker was also not significantly correlated with the tumor proliferation activity index ki-67. Univariate analysis showed that the 5-year overall survival and tumor-free survival of patients with low expression of β-cate-nin were significantly lower than those of high-expression patients (53.2%, 29.0% and 81.9%, 76.0%, respectively) (P < 0.05). Among the prognostic factors influencing tumor-free survival rate, the difference of α-catenin reached the critical significance (P = 0.061). Conclusion: The abnormal expressions of α-, β- and γ-catenin and cyclinD1 in nasopharyngeal carcinoma tissues were found. There was no correlation between the abnormal expression and tumor proliferation, staging and metastasis. Only a decrease in β-catenin expression is an adverse prognostic factor affecting patient survival. The detection of the clinical significance of these molecular markers must be expanded sample size, it is possible to provide the basis for future molecular targeted therapy.