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细胞色素Ｐ４５０２Ｄ６（ＣＹＰ２Ｄ６）是一种重要的Ｐ４５０系氧化代谢酶，除参与代谢一些内源性物质和某些环境中毒性化合物外，主要是参与多种重要药物的代谢，如作用于心血管和中枢神经系统的药物。ＣＹＰ２Ｄ６参与代谢的药物占总Ｐ４５０代谢药物的３０％，同时对手性药物的代谢还呈现立体选择性。研究还发现ＣＹＰ２Ｄ６对药物的代谢呈现明显的个体和种族差异，引起这种差异的主要原因是ＣＹＰ２Ｄ６具有的基因多态性，此外还有一些非基因因素，如药物的影响等。目前，ＣＹＰ２Ｄ６的生物学特征已被基本确定，这将十分有助于对ＣＹＰ２Ｄ６的深入研究，从而为临床合理用药提供科学依据。
Cytochrome P4502D6 (CYP2D6) is an important P450 oxidative metabolic enzyme. It participates in the metabolism of many important drugs in addition to the metabolism of some endogenous substances and certain environmental toxic compounds, such as cardiovascular and Central nervous system drugs. CYP2D6 involved in the metabolism of drugs accounted for 30% of the total metabolism of P450, while the metabolism of chiral drugs also showed stereoselectivity. The study also found that CYP2D6 drug metabolism showed significant individual and ethnic differences, the main reason for this difference is CYP2D6 genetic polymorphism, in addition to some non-genetic factors, such as the impact of drugs. At present, the biological characteristics of CYP2D6 have been basically determined, which will be very helpful for the further study of CYP2D6, so as to provide a scientific basis for clinical rational drug use.