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目的探讨大黄素对急性放射性肠炎的疗效及作用机制。方法选用SD大鼠53只,随机分为正常组、模型组、白头翁汤组和大黄素组。采用6MV高能X射线建立急性放射性肠炎大鼠模型,连续灌胃给药7 d,光学显微镜下观察及图像分析仪测定其相关的形态学指标,并测定小肠组织匀浆NO含量、SOD活性及MDA含量。结果 大黄素组大鼠肠组织绒毛高度、隐窝深度、黏膜及全层壁厚度均显著高于模型组(P<0.05),与白头翁汤组比较无明显差异(P>0.05);大黄素组肠组织匀浆NO含量及MDA含量与模型组比较均显著降低(P<0.05),SOD活性则显著升高(P<0.05);与白头翁汤组比较,NO含量显著降低(P<0.05),SOD活性及MDA含量无明显差异(P>0.05)。结论 大黄素可明显升高小肠组织绒毛高度、隐窝深度、黏膜及全层壁厚度,减少组织NO生成,减轻炎症反应及组织过氧化损伤。
Objective To investigate the efficacy and mechanism of emodin on acute radiation enteritis. Methods Fifty-three SD rats were randomly divided into normal group, model group, Pulsatilla Decoction group and emodin group. Acute radiation enteritis rat model was established by 6MV high energy X-ray. The rats were gavaged for 7 days. The morphological indexes were determined by light microscope and image analyzer. The contents of NO, SOD and MDA content. Results Emodin group, intestinal villus height, crypt depth, mucosa and the thickness of the entire wall were significantly higher than the model group (P <0.05), Pulsatilla soup group was no significant difference (P> 0.05); emodin group Compared with the model group, the content of NO and the content of MDA in the intestinal homogenate were significantly decreased (P <0.05) and the activity of SOD was significantly increased (P <0.05) SOD activity and MDA content had no significant difference (P> 0.05). Conclusion Emodin can significantly increase the villus height, crypt depth, mucosa and the thickness of the entire wall of intestinal tissue, reduce the production of NO, reduce the inflammatory reaction and the tissue peroxidation injury.