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目的了解连云港市赣榆区1~10岁组健康儿童流行性脑脊髓膜炎A群和C群(以下简称A群流脑和C群流脑)、百日咳、白喉及破伤风特异性抗体水平,为免疫规划工作提供参考依据。方法采用随机抽样的方法,共采集1~10岁组健康儿童手指血样18 747份,分离血清;采用酶联免疫吸附试验法检测上述5种传染病特异性Ig G抗体水平;对实验数据进行统计分析。结果调查的18 747份有效样本中,A群流脑和C群流脑、百日咳、白喉及破伤风Ig G抗体阳性率分别为97.9%、98.0%、99.1%、98.5%、99.0%,4~10岁组高于1~3岁组;百日咳抗体1~3岁组高于4~10岁组;百日咳、白喉抗体阳性率的地区组间差异为平原>山区>沿海;其它抗体阳性率在调查对象的年龄、地区之间无差异。结论连云港市赣榆区1~10岁组健康儿童上述5类传染病特异性抗体均维持在较高水平,可以有效控制该传染病的暴发和流行。
Objective To understand the levels of specific antibodies against group A and group C (hereinafter referred to as group A meningitis and group C) of infectious meningitis, pertussis, diphtheria and tetanus in healthy children aged 10 to 10 years in Ganyu District, Lianyungang City, Provide a reference for immunization planning work. Methods A total of 18 747 finger blood samples were collected from healthy children aged from 1 to 10 years, and the serums were separated by random sampling method. The levels of the specific Ig G antibodies of the five infectious diseases were detected by enzyme linked immunosorbent assay. The experimental data were statistically analyzed analysis. Results Among the 18 747 valid samples investigated, the positive rates of Ig G antibodies against meningococcal group A, group C meningitis, whooping cough, diphtheria and tetanus were 97.9%, 98.0%, 99.1%, 98.5%, 99.0% The prevalence of pertussis and diphtheria antibody in the 10-year-old group was higher than that in the 1-3 year-old group; the antibody levels of pertussis in the 1-3-year-old group were higher than those in the 4-10-year-old group; The age of the subject, no difference between regions. Conclusion The above 5 types of infectious disease-specific antibodies in healthy children aged 10 to 10 years in Ganyu district of Lianyungang City were maintained at a high level, which could effectively control the outbreak and epidemic of the infectious disease.