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目的:观察胃癌及癌前病变(肠上皮化生、不典型增生)组织中血管内皮细胞生长因子(VEGF)和诱导型一氧化氮合酶(iNOS)的表达,探讨其临床意义。方法:选择我院2008-01/2010-01手术切除和内镜活检的胃黏膜标本150例,其中胃黏膜肠上皮化生组50例,不典型增生组50例,胃癌组50例;另40例来自胃镜胃黏膜活检的正常胃黏膜标本作为对照组。免疫组化染色法比较各组VEGF和iNOS的表达。结果:胃癌组VEGF和iNOS的表达高于其余3组(P<0.01);肠上皮化生组与不典型增生组的表达无显著差异;但均明显高于对照组(P<0.05)。结论:胃镜黏膜组织活检VEGF和iNOS的表达与组织恶变程度相关,有利于胃癌的早期诊断。
Objective: To observe the expression of vascular endothelial growth factor (VEGF) and inducible nitric oxide synthase (iNOS) in gastric carcinoma and precancerous lesions (intestinal metaplasia and dysplasia), and to explore its clinical significance. Methods: 150 cases of gastric mucosa resected and endoscopic biopsy in our hospital from January 2008 to January 2010 were selected, including 50 cases of gastric mucosa intestinal metaplasia group, 50 cases of dysplasia group and 50 cases of gastric cancer group. For example, normal gastric mucosa specimens from gastroscopic gastric biopsy served as control group. Immunohistochemical staining was used to compare the expression of VEGF and iNOS in each group. Results: The expressions of VEGF and iNOS in gastric cancer group were higher than those in the other three groups (P <0.01). There were no significant differences in the expression of VEGF and iNOS between the intestinal metaplasia group and the atypical hyperplasia group (P <0.05). Conclusions: The expression of VEGF and iNOS in gastroscopic mucosa biopsy is correlated with the malignant degree of tissue, which is good for the early diagnosis of gastric cancer.