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目的 观察生长抑素 (施他宁 )对重症急性胰腺炎的治疗效果及其对急性胰腺炎患者血浆内毒素和 TNF︿水平的影响。方法 36例急性重症胰腺炎患者随机分为 A、B两组 ,A组采用施他宁治疗 (治疗组 ) ,B组给予一般常规治疗 (对照组 ) ,于第 1～ 7天抽血测定血清淀粉酶、血浆内毒素和 TNF︿。结果 急性胰腺炎患者入院第一天的血浆内毒素 (A/ B组 :0 .95± 0 .2 2 / 0 .96± 0 .2 7IU/ ml)和 TNF︿水平 (A/ B组 :0 .87± 0 .2 7/ 0 .86± 0 .2 1 ng/ ml)均明显高于健康人 (内毒素 /TNF︿:0 .1 1± 0 .0 3 IU/ ml/ 0 .0 4± 0 .0 2 ng/ ml) ;治疗组患者血清淀粉酶、血浆内毒素和 TNF︿水平下降速度明显快于对照组。结论 急性胰腺炎患者早期均存在不同程度的内毒素血症及血浆TNF︿水平升高 ,生长抑素治疗急性重症胰腺炎疗效肯定 ,治疗组患者血浆内毒素和 TNF︿水平下降均明显快于对照组。
Objective To observe the effect of somatostatin (Sitatlon) on the treatment of severe acute pancreatitis and its effect on plasma endotoxin and TNF-α levels in patients with acute pancreatitis. Methods Thirty-six patients with severe acute pancreatitis were randomly divided into A and B groups. A group was treated with shitamine (treatment group), B group was given routine treatment (control group), blood was collected on days 1-7 Amylase, plasma endotoxin and TNF alpha. Results The levels of plasma endotoxin (A / B: 0 .95 ± 0.22 / 0 .96 ± 0.27 IU / ml) and TNFα level on the first day of hospital admission in patients with acute pancreatitis (A / B group: .87 ± 0. 27/0 .86 ± 0. 2 1 ng / ml) were significantly higher than those in healthy subjects (endotoxin / TNFα: 0.11 ± 0.30 IU / ml / ± 0. 02 ng / ml). The serum amylase, plasma endotoxin and tumor necrosis decreased significantly in the treatment group than in the control group. Conclusions All patients with acute pancreatitis have different levels of endotoxemia and elevated levels of tumor necrosis factor in the early stage. The efficacy of somatostatin in the treatment of acute severe pancreatitis is affirmed. The levels of plasma endotoxin and tumor necrosis factor group.