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目的观察缬沙坦联合氨氯地平治疗老年原发性高血压合并糖尿病患者的效果。方法将90例中老年原发性高血压合并糖尿病患者随机分为观察组和对照组各45例,对照组患者采用缬沙坦治疗,观察组患者采用缬沙坦联合氨氯地平治疗。对比2组治疗前后生化指标和不良反应发生率。结果治疗前2组血尿素氮、血肌酐、内生肌酐清除率和空腹血糖水平比较差异无统计学意义(P>0.05)。治疗后,2组生化指标均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为4.44%低于对照组的26.67%,差异有统计学意义(P<0.05)。结论缬沙坦联合氨氯地平治疗老年原发性高血压合并糖尿病患者具有良好的治疗效果,值得临床推广应用。
Objective To observe the effect of valsartan combined with amlodipine in the treatment of elderly patients with essential hypertension and diabetes mellitus. Methods Ninety elderly patients with essential hypertension and diabetes mellitus were randomly divided into observation group (45 cases) and control group (45 cases). Patients in the control group were treated with valsartan. Patients in the observation group were treated with valsartan combined with amlodipine. The biochemical indexes and the incidence of adverse reactions before and after treatment were compared between two groups. Results Before treatment, the blood urea nitrogen, serum creatinine, endogenous creatinine clearance rate and fasting blood glucose level had no significant difference (P> 0.05). After treatment, the two groups of biochemical indicators were lower than before treatment, and the observation group was lower than the control group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the observation group was 4.44% lower than that in the control group (26.67%), the difference was statistically significant (P <0.05). Conclusion Valsartan combined with amlodipine treatment of elderly patients with essential hypertension with diabetes has a good therapeutic effect, it is worthy of clinical promotion and application.