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目的探讨高原高寒环境下肢体枪弹伤后机体糖、蛋白质、脂肪代谢的变化特点。方法将24只小型猪随机分为高原战时组(GZ)、高原平时组(GP)和平原平时组(PP),分别于伤前、伤后30min、2h、6h、12h、1d、2d、3d、5d、7d、10d、14d采静脉血,测定血糖、乳酸、游离脂肪酸和总氨基酸。同时于伤前、伤后7d和14d称量动物的体重。结果 (1)伤后30min,PP组、GP组、GZ组的血糖分别为伤前的142%、156%和179%,PP组、GP组分别于伤后1d和3d时与伤前无显著差异,而GZ组直到伤后14d仍显著高于伤前水平。(2)伤后30min,PP组、GP组、GZ组的血乳酸分别为伤前的203%、204%和233%,3组分别于伤后1d、2d和3d时与伤前无显著差异。(3)伤后6h及2h,PP组和GP组血游离脂肪酸分别降至最低点,分别为伤前值的71.3%和33.9%,均于伤后2d恢复至伤前值,至7d时达高峰,分别为伤前的138%和177%。而GZ组伤前就是GP组的267%,伤后2h为伤前的51.9%,此后逐渐升高,至1d后稳定在伤前的84%上下,始终高于GP和PP两组。(4)伤后3组总氨基酸早期升高幅度依次为GZ>GP>PP,PP组伤后12h时、GP组伤后7d时与伤前无统计学差异,GZ组伤后14d仍高于GP组。(5)伤后动物生长速度依次为GZGP>PP。
Objective To investigate the changes of body sugar, protein and fat metabolism following bullet wounds in the plateau and alpine environment. Methods Twenty-four miniature pigs were randomly divided into three groups: GZ group, GP group and PP group. The animals were sacrificed before injury, 30min, 2h, 6h, 12h, 1d, 2d, Venous blood was collected at 3d, 5d, 7d, 10d and 14d for blood glucose, lactate, free fatty acids and total amino acids. At the same time, animals were weighed before injury, 7d and 14d after injury. Results (1) The blood glucose of PP group, GP group and GZ group were 142%, 156% and 179% respectively at 30 min after injury, and there was no significant difference between the PP group and the GP group at 1 d and 3 d While the GZ group was significantly higher than the pre-injury level 14 days after injury. (2) The blood lactic acid of PP group, GP group and GZ group was 203%, 204% and 233% respectively at 30min after injury, and there was no significant difference between the three groups at 1d, 2d and 3d after injury . (3) At 6h and 2h after injury, the levels of free fatty acids in PP and GP groups decreased to 71.3% and 33.9%, respectively, Peaks were 138% and 177% respectively before the injury. However, the GZ group was 267% of the GP group before injury, 51.9% of the pre-injury 2h after injury, and then gradually increased to 84% of the pre-injury level after 1 day, always higher than the GP and PP groups. (4) There was no significant difference in the early increase of total amino acids among the three groups after injury (GZ> GP> PP), at 12h after injury in PP group, and no significant difference at 7d after injury between G group and 14d after GZ injury GP group. (5) The animal growth rate after injury was GZ GP> PP.