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目的观察多潘立酮混悬液联合复方阿嗪米特肠溶片治疗小儿功能性消化不良的效果。方法该院儿科门诊165例功能性消化不良患儿,按随机数字表法分为A、B、C三组各55例。A组服用多潘立酮混悬液三餐前15~30分钟口服,0.2~0.3ml/kg,最大剂量10ml;B组复方阿嗪米特肠溶片三餐后服用,4~10岁每次1片,10~12岁每次2片;C组多潘立酮混悬液联合复方阿嗪米特肠溶片,用法、用量同A、B组。三组均连用4周,用药2周后进行疗效评定,治疗结束后评定临床症状积分。结果 C组治愈率50.9%,均高于A、B组的30.9%和25.6%,腹痛、腹胀积分显著低于A、B两组;组间差异有统计学意义。不良反应发生率A组3.6%、B组5.5%、C组7.3%,组间差异无统计学意义。结论多潘立酮混悬液联合复方阿嗪米特肠溶片治疗小儿功能性消化不良,能明显改善腹胀、腹痛症状,还能提高疗效,安全性也较高。
Objective To observe the effect of domperidone suspension combined with compound azinamid enteric-coated tablets in the treatment of functional dyspepsia in children. Methods 165 cases of functional dyspepsia in pediatric outpatient department of the hospital were divided into A, B and C groups of 55 cases according to random number table. Group A took domperidone suspension three to three minutes before meals orally, 0.2 ~ 0.3ml / kg, the maximum dose of 10ml; B group of compound azinamid enteric-coated tablets after taking three meals, 4 to 10 years old each one , 10 to 12 years old each 2; C group domperidone suspension combined with compound azinamid enteric-coated tablets, usage, the same amount with A, B group. The three groups were used in combination for 4 weeks, and the curative effect was evaluated after 2 weeks of treatment. The clinical symptom scores were evaluated after the treatment. Results The cure rate of group C was 50.9%, which was higher than that of group A and group B by 30.9% and 25.6% respectively. The scores of abdominal pain and abdominal distension were significantly lower than those of group A and group B; the difference was statistically significant. The incidence of adverse reactions was 3.6% in group A, 5.5% in group B and 7.3% in group C, with no significant difference between groups. Conclusion Domperidone suspension combined with compound azinamid enteric-coated tablets for the treatment of functional dyspepsia in children can significantly improve the symptoms of bloating and abdominal pain, improve the curative effect and have higher safety.