应用常规染色体畸变分析和胞浆分裂阻滞微核法检测了海洛因依赖者外周血淋巴细胞染色体畸变率和微核率，并将海洛因依赖组微核率和微核细胞率与正常对照相比较。结果表明，海洛因依赖组微核细胞率和微核率显著高于对照，但不能排除吸烟的影响；在海洛因依赖组中所观察到的染色体畸变主要为单间隙． Chromosome aberration and micronucleus rate of peripheral blood lymphocytes of heroin addicts were detected by routine chromosome aberration analysis and cytokinesis-block micronucleus test. The rates of micronuclei and micronucleated cells in heroin addicts were compared with those of normal controls. The results showed that the rates of micronuclei and micronuclei in heroin dependence group were significantly higher than those in control group, but the effects of smoking were not excluded. The chromosomal aberrations observed in heroin dependence group were mainly single gaps.